Abstract Types

CRA
Clinical Review Abstract

LBA
Late-Breaking Abstract

TPS
Trials in Progress Abstract

e
Abstracts selected for publication but not presentation at the Annual Meeting

^
Abstracts granted an exception in accordance with ASCO's Conflict of Interest Policy



A randomized phase III comparison of standard-dose (60 Gy) versus high-dose (74 Gy) conformal chemoradiotherapy with or without cetuximab for stage III non-small cell lung cancer: Results on radiation dose in RTOG 0617.

Sub-category:
Local-regional Non-small Cell Lung Cancer

Category:
Lung Cancer - Non-small Cell Local-regional/Small Cell/Other Thoracic Cancers

Meeting:
2013 ASCO Annual Meeting

Abstract No:
7501

Citation:
J Clin Oncol 31, 2013 (suppl; abstr 7501)

Publication-only abstracts (abstract number preceded by an "e"), published in conjunction with the 2013 Annual Meeting but not presented at the Meeting, can be found online only.

Author(s): Jeffrey D Bradley, Rebecca Paulus, Ritsuko Komaki, Gregory A. Masters, Kenneth Forster, Steven E. Schild, Jeffrey Bogart, Yolanda I. Garces, Samir Narayan, Vivek Kavadi, Lucien Alexander Nedzi, Jeff M. Michalski, Douglas Johnson, Robert Malcolm MacRae, Walter John Curran, Hak Choy, Radiation Therapy Oncology Group; Washington University School of Medicine in St. Louis, St. Louis, MO; Radiation Therapy Oncology Group, Statistical Center, Philadelphia, PA; The University of Texas MD Anderson Cancer Center, Houston, TX; Helen F. Graham Cancer Center, Christiana Care, Newark, DE; Moffitt Cancer Center, Tampa, FL; Mayo Clinic, Scottsdale, AZ; SUNY Upstate Medical University, Syracuse, NY; Mayo Clinic, Rochester, MN; St Joseph Mercy Hosp, Ann Arbor, MI; Texas Oncology, Sugarland, TX; The University of Texas Southwestern Medical Center, Dallas, TX; Florida Radiation Oncology Group, Jacksonville, FL; The Ottawa Hospital, Ottawa, ON, Canada; Emory University, Atlanta, GA

Abstract Disclosures


Abstract:

Background: The first objective of RTOG 0617 was to compare the overall survival(OS) of patients(pts) treated with standard-dose(SD)(60Gy) versus high-dose(HD)(74Gy) radiotherapy with concurrent chemotherapy(CT). Methods: This Phase III Intergroup trial randomized 464 pts with Stage III NSCLC to the SD(60Gy) vs. HD(74Gy) arms prior to closure of the HD arm. Concurrent CT included weekly paclitaxel(45 mg/m2) and carboplatin(AUC=2). Pts randomized to cetuximab received a 400 mg/m2 loading dose on Day 1 followed by weekly doses of 250 mg/m2. All pts were to receive consolidation CT. We are reporting the final results on radiation dose. Results: 464 pts were accrued prior to closure of the HD arm in 6/11, of which 419 were eligible for analysis. Median follow up was 17.2 months. There were 2 and 10 grade 5 treatment-related adverse events(AEs) on the SD and HD arms, respectively. Grade 3+AEs were 74.2% and 78.2% on SD and HD arms, respectively (p=0.34). The median survival times and 18-month OS rates for the SD and HD arms were 28.7 vs 19.5 months, and 66.9% vs 53.9% respectively (p=0.0007). The primary cause of death was lung cancer (72.2% vs 73.5%)(p=0.84). Local failure rates at 18 months were 25.1% vs 34.3% for SD and HD patients, respectively(p=0.03). Local-regional and distant failures at 18 months were 35.3% vs 44%(p=0.04) and 42.4% vs 47.8%(p=0.16) for SD and HD arms, respectively. Factors predictive of less favorable OS on multivariate analysis were higher radiation dose, higher esophagitis/dysphagia grade, greater gross tumor volume, and heart volume >5 Gy. Conclusions: In this setting of chemoradiation for locally-advanced Stage III NSCLC, 60 Gy is superior to 74 Gy in terms of OS and local-regional control. The effect of the anti-EGFR antibody (cetuximab) awaits further follow up. This project was supported by RTOG grant U10 CA21661, CCOP grant U10 CA37422, and ATC U24 CA 81647 from the National Cancer Institute (NCI) and Eli Lilly and Company. Clinical trial information: NCT00533949.

 

  Other Abstracts in this Sub-Category:

 

1. START: A phase III study of L-BLP25 cancer immunotherapy for unresectable stage III non-small cell lung cancer.

Meeting: 2013 ASCO Annual Meeting Abstract No: 7500 First Author: C. A. Butts
Category: Lung Cancer - Non-small Cell Local-regional/Small Cell/Other Thoracic Cancers - Local-regional Non-small Cell Lung Cancer

 

2. Impact of brachytherapy on local recurrence after sublobar resection: Results from ACOSOG Z4032 (Alliance), a phase III randomized trial for high-risk operable non-small cell lung cancer (NSCLC).

Meeting: 2013 ASCO Annual Meeting Abstract No: 7502 First Author: H. C. Fernando
Category: Lung Cancer - Non-small Cell Local-regional/Small Cell/Other Thoracic Cancers - Local-regional Non-small Cell Lung Cancer

 

3. Surgery for NSCLC stages T1-3N2M0 having preoperative pathologically verified N2 involvement: A prospective randomized multinational phase III trial by the Nordic Thoracic Oncology Group.

Meeting: 2013 ASCO Annual Meeting Abstract No: 7504 First Author: J. Sorensen
Category: Lung Cancer - Non-small Cell Local-regional/Small Cell/Other Thoracic Cancers - Local-regional Non-small Cell Lung Cancer

 

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